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Plasma catecholamine and cortisol concentrations during acceleration stress

Y Miyamoto1, H Shimazu, A Nakamura

  • 1Aeromedical Laboratory, Japan Air Self Defense Force, Tokyo.

European Journal of Applied Physiology and Occupational Physiology
|January 1, 1995
PubMed
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Human subjects exposed to +5Gz acceleration stress showed distinct changes in stress hormones. Adrenaline and noradrenaline increased post-exposure, while cortisol decreased, highlighting the complexity of physiological responses to G-force.

Area of Science:

  • Aerospace Medicine
  • Human Physiology
  • Stress Response

Background:

  • Acceleration stress significantly impacts human physiology.
  • Understanding hormonal responses to G-force is crucial for safety and performance.
  • Previous studies lacked continuous monitoring of catecholamines and cortisol during acceleration.

Purpose of the Study:

  • To investigate the serial changes in catecholamine (CA) and cortisol (Col) concentrations during and after head-to-foot (+5Gz) acceleration stress.
  • To compare the dynamic responses of noradrenaline (NA), adrenaline (A), and cortisol (Col) to G-force exposure.
  • To assess the utility of continuous blood sampling for analyzing hormonal responses to acceleration stress.

Main Methods:

  • Human subjects were exposed to +5Gz acceleration for 1 minute.

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  • A novel continuous blood sampling system was employed.
  • Concentrations of noradrenaline, adrenaline, and cortisol were serially measured before, during, and after Gz exposure.
  • Heart rate was monitored throughout the experiment.

    • Main Results:

    • Noradrenaline levels remained stable during exposure, peaking 110s post-exposure (3-fold increase).
    • Adrenaline levels increased gradually during and after exposure, peaking 110s post-exposure (7-fold increase).
    • Cortisol levels decreased during Gz exposure, potentially due to enhanced plasma removal.

    Conclusions:

    • Hormonal responses to G-force are complex and differ significantly between catecholamines and cortisol.
    • Adrenaline's rapid and substantial increase suggests significant emotional and physical stress during acceleration.
    • Continuous monitoring is vital for accurately analyzing hormonal dynamics under G-force stress.