Related Experiment Videos
Ultraviolet B irradiation increases endothelin-1 and endothelin receptor expression in cultured human keratinocytes
1Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan.
FEBS Letters
|September 4, 1995
Abstract:
The effect of ultraviolet B (UVB) irradiation on endothelin-1 (ET-1) and ET receptor expression was examined using cultured normal human keratinocytes. Keratinocytes secreted ET-1 in the medium at a level of 2.1 pg/day/10(5) cells. UVB irradiation up to 10 mJ/cm2 increased ET-1 secretion 3-fold, and potentiated expression of mRNA for ET-1. Both ETA and ETB receptor mRNAs were detected in keratinocytes, and their expression was up-regulated by 5 mJ/cm2 UVB irradiation.