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Related Experiment Videos

Delayed-type hypersensitivity to human gonadotropin: case report

A Redfearn1, E G Hughes, M O'Connor

  • 1McMaster University, Hamilton, Ontario, Canada.

Fertility and Sterility
|October 1, 1995
PubMed
Summary

Women undergoing IVF experienced adverse reactions to human menopausal gonadotropin (hMG) injections. Switching to a purified preparation of human follicle-stimulating hormone (hFSH) successfully prevented these allergic responses.

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Area of Science:

  • Reproductive Endocrinology
  • Allergy and Immunology
  • In Vitro Fertilization (IVF)

Background:

  • Adverse reactions to human menopausal gonadotropin (hMG) can complicate infertility treatments.
  • Investigating the immunological basis of these reactions is crucial for patient safety in IVF programs.

Observation:

  • Two women in IVF programs developed local reactions and systemic symptoms after hMG injections.
  • Skin testing revealed delayed hypersensitivity (DH) to hMG in affected patients.
  • Biopsy of a reaction site confirmed a delayed hypersensitivity response.

Findings:

  • Affected patients showed a positive delayed hypersensitivity skin response to hMG.
  • A negative skin test result was observed with purified human follicle-stimulating hormone (hFSH).

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  • hFSH was administered without adverse effects in these patients.

    • Implications:

    • The findings suggest that allergic reactions to hMG in IVF patients are mediated by delayed hypersensitivity.
    • Switching to purified hFSH preparations can prevent these adverse reactions.
    • This highlights the importance of evaluating drug hypersensitivity in assisted reproductive technologies.