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High-dose chemotherapy with autologous bone marrow transplantation for refractory metastatic gestational
P L Giacalone1, P Benos, D Donnadio
1Department of Obstetrics and Gynecology, Hopital Arnaud de Villeneuve, Montpellier, France.
Abstract:
A patient with gestational trophoblastic disease failed to respond to all standard multiple-agent chemotherapy and had progressive uterine disease. Total hysterectomy also proved ineffective. We therefore administered high-dose cyclophosphamide, etoposide, and melphalan with autologous bone marrow support. Severe marrow suppression followed but a complete remission was achieved and the patient remains free of disease 3 years after the completion of therapy. This result seems to confirm the value of using high-dose multiagent therapy to optimize the dose-effect of therapy regimens on drug-refractory gestational trophoblastic disease.