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Epithelioid glomus tumor

D R Pulitzer1, P C Martin, R J Reed

  • 1Department of Pathology, University of Texas Health Science Center, San Antonio 78284-7750, USA.

Human Pathology
|September 1, 1995
PubMed
Summary

This study describes epithelioid glomus tumors, a rare variant with distinct cell morphology. These tumors, while appearing atypical, share characteristics with conventional glomus tumors and are successfully treated with surgical excision.

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Area of Science:

  • Pathology
  • Oncology
  • Dermatology

Background:

  • Glomus tumors are typically composed of small, uniform cells.
  • An unusual histological variant, epithelioid glomus tumor, is presented.
  • This variant exhibits distinct cellular morphology compared to conventional glomus tumors.

Observation:

  • Epithelioid glomus tumors consist of large polygonal to spindle-shaped cells with abundant eosinophilic cytoplasm and irregular nuclei.
  • These cells possess both epithelioid and myoid qualities.
  • Cytological atypicality in epithelioid areas is attributed to degeneration or senescence, not neoplastic progression.

Findings:

  • Immunohistochemical and ultrastructural studies confirm smooth muscle derivation, identical to conventional glomus tumors.
  • The differential diagnosis for epithelioid glomus tumors includes benign and malignant epithelial and spindle-cell lesions.
  • Simple surgical excision was curative in all reported cases with follow-up.

Implications:

  • Recognition of epithelioid glomus tumors is crucial to avoid misdiagnosis with other neoplastic lesions.
  • Understanding the benign nature of cellular atypia aids in accurate diagnosis and patient management.
  • This report highlights a previously undescribed variant of glomus tumor, expanding diagnostic knowledge.

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