Isolated uvular angioedema associated with ACE inhibitor use

Area of Science:

• Pharmacology
• Internal Medicine
• Otolaryngology

Background:

• Angiotensin-converting enzyme (ACE) inhibitors are widely prescribed for hypertension and heart failure.
• Angioedema is a recognized, though uncommon, adverse effect of ACE inhibitor treatment.
• Uvular involvement in angioedema is rare, potentially leading to airway compromise.

Observation:

• A case of isolated uvular angioedema is presented in a patient receiving lisinopril.
• The patient experienced swelling localized exclusively to the uvula.
• This presentation highlights a rare manifestation of ACE inhibitor-induced angioedema.

Findings:

• The report documents a specific instance of lisinopril-induced angioedema affecting only the uvula.
• It underscores the variability in clinical presentation of this adverse drug reaction.
• Review of management strategies for uvular edema is included.

Implications:

• Clinicians should consider ACE inhibitor-induced angioedema in patients presenting with uvular swelling, even in the absence of other symptoms.
• Prompt recognition and appropriate management are crucial to prevent airway obstruction.
• This case contributes to understanding the spectrum of angioedema associated with ACE inhibitors.