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Isolation and structure of two novel muscarinic receptor antagonists
V R Hedge1, J E Silver, M G Patel
1Schering-Plough Research Institute, Kenilworth, New Jersey 07033-0539, USA.
Journal of Natural Products
|June 1, 1995
Abstract:
The structures of two novel muscarinic receptor antagonists, 1 and 2, were determined by their spectral data and high-resolution mass measurements of their degradation products. Both are aliphatic long-chain compounds and contain amide and keto functionalities. The major microbial metabolite [1] contains three terminal guanidino groups and the minor compound [2] has two terminal guanidino groups.