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Related Experiment Videos

Nailfold capillary abnormalities in Behçet's disease

G Vaiopoulos1, N Pangratis, M Samarkos

  • 1First Department of Internal Medicine, Athens University Medical School, Laiko General Hospital, Greece.

The Journal of Rheumatology
|June 1, 1995
PubMed
Summary
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Nailfold capillary abnormalities are common in Behçet

Area of Science:

  • Rheumatology
  • Dermatology
  • Vascular Biology

Background:

  • Behçet's disease is a multisystem vasculitis with diverse clinical manifestations.
  • Nailfold capillaroscopy is a non-invasive technique to assess microvascular changes.

Purpose of the Study:

  • To quantify the prevalence and severity of nailfold capillary abnormalities in Behçet's disease.
  • To investigate the correlation between these microvascular changes and clinical features.

Main Methods:

  • Stereomicroscopic examination of nailfold capillaries in 33 Behçet's disease patients and 40 healthy controls.
  • Classification of capillary abnormalities using Fagrell's stages (0, A, B, C).

Main Results:

  • 75% of Behçet's disease patients exhibited nailfold capillary abnormalities (stages A, B, C), compared to 7% in controls.

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  • Abnormal capillary findings significantly correlated with skin manifestations, arthritis/arthralgia, and a positive pathergy test.
  • No significant correlation was found between capillary stages and eye involvement or disease duration.

    • Conclusions:

    • Nailfold capillaroscopy is a valuable non-invasive tool for detecting microvascular abnormalities in Behçet's disease.
    • The presence and severity of these abnormalities are associated with specific clinical manifestations of the disease.