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A controlled study on serum insulin-like growth factor-I and urinary excretion of growth hormone in fibromyalgia
S Jacobsen1, K Main, B Danneskiold-Samsøe
1Department of Rheumatology, Hvidovre Hospital, University of Copenhagen, Denmark.
Objective:
It has been hypothesized that secretory deficiencies of growth hormone may play a pathophysiological role in fibromyalgia (FM). Our objective was thus to evaluate the secretion of growth hormone in FM.
Methods:
The 24-h urinary growth hormone excretion and serum levels of insulin-like growth factor-I (IGF-I) was measured in 17 middle aged women with FM and 19 healthy women. The degree of subjective sleep disturbance was also determined.
Results:
Sleep was significantly more disturbed in the patients than the controls. We found no significant differences in the urinary excretion of growth hormone and serum levels of IGF-I between patients with FM and healthy controls.
Conclusion:
Major secretory deficiencies were not documented. However, the power of our study does not allow us to discard the role of minor secretory deficiencies of human growth hormone in FM.
