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Hyperbaric oxygen treatment for haemorrhagic radiation cystitis
R F Bevers1, D J Bakker, K H Kurth
1Academic Medical Center, University of Amsterdam, The Netherlands.
Lancet (London, England)
|September 23, 1995
Summary
Hyperbaric oxygen therapy effectively treats radiation-induced hemorrhagic cystitis and severe hematuria. This treatment offers significant symptom relief with no reported adverse effects, making it a viable option for patients.
Area of Science:
- Urology
- Oncology
- Hyperbaric Medicine
Background:
- Radiation-induced hemorrhagic cystitis is a challenging complication of pelvic radiotherapy.
- Conventional treatments often fail to resolve the underlying radiocystitis, primarily managing hematuria.
Purpose of the Study:
- To evaluate the efficacy and safety of hyperbaric oxygen therapy for radiation-induced hemorrhagic cystitis with severe hematuria.
Main Methods:
- A prospective study involving 40 patients with biopsy-proven radiation cystitis and severe hematuria.
- Patients received 20 sessions of 100% oxygen inhalation at 3 bar for 90 minutes in a multiplace hyperbaric chamber.
Main Results:
- Significant improvement or complete resolution of hematuria was observed in 37 out of 40 patients.
- The mean follow-up period was 23.1 months, with a low recurrence rate of 0.12 per year.
- No adverse effects were reported during or after the hyperbaric oxygen treatment.
Conclusions:
- Hyperbaric oxygen therapy is a safe and effective treatment for radiation-induced hemorrhagic cystitis and severe hematuria.
- It addresses both the symptoms (hematuria) and the underlying condition (radiocystitis).
- Consideration of hyperbaric oxygen therapy is recommended for patients suffering from severe radiation-induced hematuria.