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Related Experiment Videos

Ocular involvement in acute lymphoblastic leukaemia

A K Tan1, A Azman, T S Hoe

  • 1Department of Ophthalmology, Hospital Kuala Lumpur.

The Medical Journal of Malaysia
|December 1, 1994
PubMed
Summary

A child in remission for acute lymphoblastic leukaemia (ALL) developed leukocoria and vision loss due to ocular involvement. This case highlights the importance of monitoring for ALL relapse in the eye, bone marrow, and central nervous system.

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Area of Science:

  • Ophthalmology
  • Pediatric Oncology
  • Hematology

Background:

  • Acute lymphoblastic leukaemia (ALL) is a common childhood cancer.
  • Remission in ALL does not preclude late relapse.
  • Ocular involvement in ALL can be a sign of systemic relapse.

Observation:

  • A 6-year-old boy with a history of ALL presented with leukocoria and decreased vision in his left eye.
  • Ocular examination revealed endophthalmitis and elevated intraocular pressure.
  • Anterior chamber paracentesis and vitreous biopsy confirmed ocular involvement.

Findings:

  • The patient was diagnosed with ocular involvement secondary to ALL relapse.
  • Further investigations confirmed concurrent bone marrow and central nervous system relapse.

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  • This case underscores the potential for diverse relapse sites in ALL.

    • Implications:

    • Ocular symptoms in ALL patients warrant thorough investigation for systemic relapse.
    • Early diagnosis of ocular involvement is crucial for timely treatment and improved outcomes.
    • Understanding the clinical manifestations and treatment of ocular leukemia is vital for pediatric oncologists and ophthalmologists.