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Related Experiment Videos

Chagas disease in pregnancy

G J Gilson1, K A Harner, J Abrams

  • 1Department of Obstetrics and Gynecology, University of New Mexico Hospital, Albuquerque, USA.

Obstetrics and Gynecology
|October 1, 1995
PubMed
Summary

Chagas disease, caused by Trypanosoma cruzi, is emerging in the US. Pregnant women can transmit this infection to their infants, necessitating increased awareness among obstetric providers.

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Area of Science:

  • Infectious Diseases
  • Tropical Medicine
  • Obstetrics & Gynecology

Background:

  • Chagas disease (American trypanosomiasis) is increasingly identified in the United States due to immigration from endemic Latin American regions.
  • Chronic Trypanosoma cruzi infection in pregnant women can manifest as cardiac or gastrointestinal issues and poses a risk of vertical transmission to the fetus.

Observation:

  • A case study involved a 32-year-old pregnant woman diagnosed with Chagas disease at 16 weeks' gestation, presenting with cardiac symptoms (left anterior hemiblock).
  • The patient's serological tests confirmed Trypanosoma cruzi infection with a high antibody titer.
  • The pregnancy proceeded normally, resulting in a healthy delivery.

Findings:

  • The infant born to the infected mother showed serological evidence of congenital Trypanosoma cruzi infection at birth (titer 1:256).

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  • The infant's antibody titer remained elevated at 6 weeks postpartum, indicating persistent infection.

    • Implications:

    • Obstetric care providers in the US must be aware of Chagas disease presentations during pregnancy.
    • Congenital Chagas disease transmission occurs in 2-10% of infected pregnancies, potentially leading to serious maternal and neonatal complications.
    • Early recognition and management are crucial for improving outcomes in pregnant women and newborns affected by Trypanosoma cruzi.