Osmoregulation of neutral amino acid transport
1Department of Physiology & Biophysics, Indiana University School of Medicine, Indianapolis 46202-5120, USA.
Abstract:
Neutral amino acids are important organic osmolytes found in most osmotically stressed cells. During prolonged hypertonic stress, accumulation of neutral amino acids contributes to the cell volume recovery and may protect cellular proteins against salt denaturation. Hypertonicity activates system A transport, a major neutral amino acid transporter in mammalian cells, by a microtubule-dependent mechanism. Similar to the regulation of amino acid efflux induced by hypotonic-swelling, influx via system A may be under the control of intracellular ionic strength. An osmotically sensitive repressor may negatively regulate the gene expression of a regulatory protein which activates the preexisting system A transporter protein. Hypertonically activated protein kinases may be involved in this osmoregulation of amino acid transport.
More Related Videos
Related Concept Videos
Secondary Active Transport
Osmoregulation in Fishes
What Are Osmoregulation and Excretion?
Secondary Active Transport
Secondary Active Transport
Reabsorption and Secretion in the Loop of Henle


