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Related Experiment Videos

CRF effect on thyroid function is not mediated by feeding behavior in goldfish

N De Pedro1, B Gancedo, A L Alonso-Gomez

  • 1Departamento de Biología Animal II (Fisiología Animal), Facultad de Ciencias Biológicas, Universidad Complutense, Madrid, Spain.

Pharmacology, Biochemistry, and Behavior
|August 1, 1995
PubMed
Summary

Corticotropin-releasing factor (CRF) impacts goldfish thyroid activity independently of feeding reduction, while refeeding significantly alters glucose and thyroid hormone levels, indicating complex interactions between nutritional status, CRF, and thyroid function.

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Area of Science:

  • Endocrinology
  • Comparative Physiology
  • Fish Biology

Background:

  • Nutritional status and stress hormones like corticotropin-releasing factor (CRF) are known to influence metabolic processes.
  • The interplay between CRF, feeding behavior, and thyroid hormone regulation in fish requires further elucidation.

Purpose of the Study:

  • To investigate the effects of acute CRF administration and refeeding on glucose and thyroid hormone levels in food-deprived goldfish.
  • To determine if CRF's impact on thyroid activity is mediated by feeding reduction.

Main Methods:

  • Goldfish were subjected to 48-hour food deprivation.
  • Acute central administration of CRF was performed.
  • Refeeding treatment was applied after fasting.
  • Plasma glucose levels, plasma thyroid hormone levels (T3 and T4), and thyroid hormone contents were measured.

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Main Results:

  • CRF administration decreased food intake and free T3 thyroid fraction but did not significantly alter plasma glucose or bound thyroid hormones.
  • CRF treatment in fasted fish reduced free T3 and increased free T4, suggesting an effect on intrathyroidal 5'-monodeiodinase activity.
  • Refeeding significantly increased free T4 content and plasma thyroid hormone levels, with plasma glucose levels also increasing.

Conclusions:

  • CRF influences goldfish thyroid activity independently of feeding reduction.
  • Nutritional status significantly impacts thyroid function, with potential overlap with CRF effects.
  • Goldfish exhibit interactions between CRF-thyroid activity and nutritional status-thyroid function.