Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

REM changes in narcolepsy with selegiline

L W Reinish1, J G MacFarlane, P Sandor

  • 1Department of Psychiatry, University of Toronto, Ontario, Canada.

Sleep
|June 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Psoriatic and psoriatic arthritis patients with and without jet-lag: does it matter for disease severity scores? Insights and implications from a pilot, prospective study.

Chronobiology international·2019
Same author

Probing the interplay between geometric and electronic-structure features via high-harmonic spectroscopy.

The Journal of chemical physics·2019
Same author

Genetic and phenotypic overlap of specific obsessive-compulsive and attention-deficit/hyperactive subtypes with Tourette syndrome.

Psychological medicine·2017
Same author

Association of the KCNJ5 gene with Tourette Syndrome and Attention-Deficit/Hyperactivity Disorder.

Genes, brain, and behavior·2014
Same author

Long-term follow-up of patients suffering from obsessive-compulsive disorder treated as in-patients.

Behavioural neurology·2014
Same author

Genome-wide association study of Tourette's syndrome.

Molecular psychiatry·2012
Same journal

Nighttime light exposure is associated with metabolic dysfunction in schizophrenia: A cross-sectional analysis of the LENS study.

Sleep·2026
Same journal

Sleep Need Outcompetes Preparation: Reframing Sleep Initiation Through Naturalistic Behaviour.

Sleep·2026
Same journal

The Quest for Automated Pediatric Sleep Scoring: Are We There Yet?

Sleep·2026
Same journal

Sex Differences in the Sleep Architecture and Sleep-Disordered Breathing in C57BL/6 J Mice.

Sleep·2026
Same journal

Differential Effects of Prenatal Depression and Anxiety on Infant Sleep: Dual-Pathway Mechanisms Involving the HPA Axis and the Gut-Brain Axis.

Sleep·2026
Same journal

Metabolic Syndrome and Obstructive Sleep Apnea: Two Sides of the Same Coin.

Sleep·2026
See all related articles

Selegiline significantly increased REM latency in narcolepsy patients, unlike methylphenidate. While methylphenidate improved alertness more, selegiline showed clinical benefits, warranting further study for narcolepsy treatment.

Area of Science:

  • Neurology
  • Sleep Medicine
  • Pharmacology

Background:

  • Narcolepsy is a chronic neurological disorder affecting sleep-wake regulation.
  • Current treatments for narcolepsy have limitations and side effects.
  • Understanding the impact of different medications on sleep architecture is crucial.

Purpose of the Study:

  • To evaluate the effects of selegiline hydrochloride on polysomnographic sleep parameters in patients with narcolepsy.
  • To compare the effects of selegiline with those of methylphenidate on sleep in narcolepsy.
  • To assess the clinical efficacy of selegiline in narcolepsy.

Main Methods:

  • Overnight polysomnography was conducted on 11 drug-free narcolepsy subjects.
  • Subjects received selegiline (15-30 mg/day) and underwent polysomnography.

Related Experiment Videos

  • A separate group of 11 age-matched narcolepsy subjects treated with methylphenidate was included for comparison.
  • Maintenance of Wakefulness Testing (MWT) was used to assess alertness.

    • Main Results:

    • Selegiline significantly increased rapid eye movement (REM) latency (p < 0.05) and sleep stage changes per hour compared to baseline.
    • Methylphenidate showed a marginally significant increase in REM latency (p = 0.054).
    • The methylphenidate group demonstrated significantly greater alertness on MWT than the selegiline group (p < 0.001).
    • A retrospective survey indicated that most subjects reported clinical improvement with selegiline.

    Conclusions:

    • Selegiline positively impacts specific sleep parameters in narcolepsy, notably increasing REM latency.
    • While methylphenidate appears more effective for daytime alertness, selegiline offers potential therapeutic benefits.
    • Selegiline warrants further investigation as a treatment option for narcolepsy.