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Updated: Aug 26, 2026
Induction of an Inflammatory Response in Primary Hepatocyte Cultures from Mice
Published on: March 10, 2017
[C-reactive protein (CRP)--an acute-phase protein with importance in laboratory medicine in veterinary medicine]
M Krüger1, W Schrödl, A Lindner
1Institut für Bakteriologie und Mykologie der Veterinärmedizinischen Fakultät der Universität Leipzig.
Abstract:
CRP is an acute phase protein (APP) formed by hepatic cells in acute phase reaction (APR). APR is initiated by a broad spectrum of cytokines of activated macrophages of blood and tissues. During the APR, plasma concentrations of APP are changed. Cytokines regulate APPs. CRP is a phylogenetically very old molecule. The degree of homology of amino acids in CRP is very high in a lot of species. CRP binding specificities depend on Ca++. The diagnostic importance of CRP in veterinary medicine is discussed.
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