[Mechanisms of protective immune response in models of Marburg fever in monkeys]

The parameters of nonspecific immunity (interferon, tumor necrosis factor, natural killers), of spontaneous and mitogen-induced lymphocyte proliferation, of specific immunity (antibodies to Marburg virus, antigen-stimulated proliferation) were found to change in the course of experimental Marburg fever in immune and intact animals. The named factors were shown to influence the course of the disease; their role in the lethal outcome of the infection was demonstrated.