Related Experiment Video
Updated: Aug 8, 2026

Strategies for Study of Neuroprotection from Cold-preconditioning
Published on: September 3, 2010
[Influence of cytokines on neuroendocrine functions during immune response. Mechanisms involved and neuronal
1Laboratoire d'endocrinologie moléculaire, Centre de recherche du CHUL, Québec, Canada.
Abstract:
The action of immune-system derived cytokines to stimulate release of corticotropin-releasing factor (CRF) from the hypothalamus and the consequent elaboration of ACTH and corticosteroids release has provided an especially useful model to investigate the nature of the inter-communication of neuroendocrine and immunological pathways. Substantial evidence also exists to support the production of cytokines within the mammalian central nervous system (CNS). These brain-derived cytokines may function to regulate specific challenges, such as immunological, trauma-induced, physical, and emotional stress, to the CNS as well as to receive input from immune signals in the systemic circulation. The mechanisms involved in the effects of cytokines, such as interleukin-1 (IL-1) alpha and beta, on selective neuroendocrine functions are presented in this review. Particularly, the neuronal circuitries used by IL-1 of peripheral and central origin to modulate neuroendocrine CRF motoneurons and the activity of the hypothalamic-pituitary-adrenal (HPA) are described. The influence of an immune activation on neuroendocrine functions and brain neuronal activation is also presented.
More Related Videos
08:47Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
Published on: May 8, 2016
11:00Multiplex Cytokine Profiling of Stimulated Mouse Splenocytes Using a Cytometric Bead-based Immunoassay Platform
Published on: November 9, 2017
Related Concept Videos
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Neurotransmitters
Encephalitis ll: Pathophysiology