Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Physiological role of PTHrP]

M Klein1, G Weryha, B Dousset

  • 1Clinique Médicale et Endocrinologique, Centre Hospitalier Régional et Universitaire de Nancy, Hôpitaux de Brabois.

Annales D'Endocrinologie
|January 1, 1995
PubMed
Summary

Parathyroid hormone related protein (PTHrP) is a key factor in humoral hypercalcemia of malignancy. This polyhormone has diverse functions beyond calcium regulation, acting through various fragments and receptors.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Five-Year Follow-Up of a Slowly Resorbable Biosynthetic P4HB Mesh (Phasix) in VHWG Grade 3 Incisional Hernia Repair.

Annals of surgery open : perspectives of surgical history, education, and clinical approaches·2023
Same author

Slowly resorbable biosynthetic mesh: 2-year results in VHWG grade 3 hernia repair.

Hernia : the journal of hernias and abdominal wall surgery·2021
Same author

Associated ileocaecal location is a marker for greater severity of low rectal endometriosis.

BJOG : an international journal of obstetrics and gynaecology·2019
Same author

A post-market, prospective, multi-center, single-arm clinical investigation of Phasix™ mesh for VHWG grade 3 midline incisional hernia repair: a research protocol.

BMC surgery·2018
Same author

Surgical procedure for multifocal duodenopancreatic gastrinomas in a MEN-1 patient (with video).

Journal of visceral surgery·2018
Same author

Adrenalectomy with nephrectomy, right hepatectomy and inferior vena cava thrombectomy for adrenocortical carcinoma (with video).

Journal of visceral surgery·2018

Area of Science:

  • Endocrinology
  • Molecular Biology

Context:

  • Parathyroid hormone related protein (PTHrP) is implicated in humoral hypercalcemia of malignancy.
  • The PTHrP gene produces multiple isoforms with N-terminal homology to parathormone (PTH).

Purpose:

  • To explore the diverse physiological roles of PTHrP.
  • To understand the functions mediated by different PTHrP fragments and their specific receptors.

Summary:

  • PTHrP exhibits widespread tissue distribution and acts as a polyhormone with functions including embryonic and mature tissue development, cellular differentiation, smooth muscle relaxation, lactation, and calcium/magnesium transport.
  • While N-terminal PTHrP binds to the classical PTH/PTHrP receptor, other fragments (midregion, carboxy-terminal) mediate distinct functions via separate receptors and signaling pathways.

Related Experiment Videos

  • These varied functions can be autocrine, paracrine, or endocrine, with some being tissue-specific.

    • Impact:

    • Elucidates the complex roles of PTHrP beyond its association with malignancy-related hypercalcemia.
    • Highlights the potential for targeted therapies by understanding fragment-specific receptor interactions.
    • Provides a foundation for further research into PTHrP's involvement in normal physiology and disease states.