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[Lipoxygenase inhibitors. IV. Synthesis and cyclization reactions of open-chain N1-aryl-substituted amidrazones]
P Frohberg1, C Kupfer, P Stenger
1Institut für Phamrazeutische Chemie der Martin-Luther-Universität Halle-Wittenberg, Halle.
Archiv Der Pharmazie
|June 1, 1995
Abstract:
alpha-Carbonyl carboxylic acid arylhydrazonochlorides obtained by Japp-Klingemann reaction are the starting substances for the synthesis of alpha-carbonyl carboxylic acid arylhydrazonoamides, -esters and -thioesters. The inhibiting activity of these compounds against 15- and 5-lipoxygenase is described. Reactions of derivatives of amidrazones with formaldehyde give triazole, triazoline and unexpected benzotriazepine derivatives.