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Updated: Jul 28, 2026
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Mutagenesis and Functional Selection Protocols for Directed Evolution of Proteins in E. coli
Published on: March 16, 2011
A general method for selecting strains of Escherichia coli having altered spontaneous or induced mutabilities
1Peptide Technology Limited, c/o CSIRO Laboratory for Molecular Biology, North Ryde NSW, Australia.
Mutation Research
|January 1, 1993
Abstract:
A simple method is described for selecting mutant strains of E. coli differing from their parent in the ability to spontaneously mutate via any mechanism. The method detects hypo- and hyper-mutators. It relies on the detection as papillae on thy colonies of second mutations either at the dra or drm locus.
