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Fine mapping of HIV-1 Nef-epitopes by monoclonal antibodies
1Institute für Virologie, Medizinischen Fakultät (Charité) der Humboldt-Universität, Berlin, Federal Republic of Germany.
Archives of Virology
|January 1, 1993
Abstract:
A panel of newly isolated murine monoclonal antibodies is described which are specific for the Nef protein of the human immunodeficiency virus type 1 (HIV-1). Epitope mapping using recombinant Nef-related proteins, synthetic peptides and lipopeptides showed 3 independent antigenic determinants located within the regions of amino acids 83-93, 175-190 and 86-166 of the Nef protein. None of the monoclonal antibodies reacted with recombinant Nef proteins of HIV-2.