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Nociceptive responses to intrathecally administered substance P and somatostatin in diabetic mice
J Kamei1, H Hitosugi, Y Kasuya
1Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
Abstract:
Male ICR mice were rendered diabetic by i.v. injection of streptozotocin. The nociceptive behavioral responses to i.t. injection of somatostatin (SST) but nor substance P (SP) were attenuated in diabetic mice compared with that in non-diabetic mice. Spantide, a SP receptor antagonist, enhanced the nociceptive response induced by i.t. SST in diabetic mice. Pretreatment of mice with SP reduced the SST-induced nociceptive response in non-diabetic mice. These results suggest that a endogenous antinociceptive system may exist which links SP with SST-mediated nociceptive transmission in the spinal cord. Furthermore, this endogenous antinociceptive system may be enhanced in diabetic mice.