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Liver damage in patients with colony-stimulating factor-producing tumors
A Suzuki1, T Takahashi, Y Okuno
1Second Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
The American Journal of Medicine
|February 1, 1993
Summary
Colony-stimulating factor (CSF)-producing tumors are linked to characteristic liver damage and leukocytosis. This suggests a novel paraneoplastic syndrome involving both elevated white blood cell counts and liver dysfunction.
Area of Science:
- Oncology
- Immunology
- Hepatology
Background:
- Colony-stimulating factor (CSF)-producing tumor cell lines also secrete interleukin-1 (IL-1) and interleukin-6 (IL-6).
- Patients with these tumors exhibit leukocytosis, fever, and liver dysfunction.
Purpose of the Study:
- To investigate the specific relationship between CSF-producing tumors and observed liver damage.
- To characterize the nature of liver pathology in patients with CSF-producing tumors.
Main Methods:
- Clinicopathologic examination of six autopsied patients with CSF-producing tumors.
- Xenotransplantation of CSF-producing tumor cell lines (KHC287, CHU-2) into nude mice.
Main Results:
- Five patients had granulocyte (G)-CSF and one had granulocyte/macrophage (GM)-CSF producing tumors; elevated IL-1 and IL-6 were noted.
- Patients showed elevated biliary enzymes and direct bilirubin, with characteristic liver pathology including focal necrosis, portal inflammation, and intrahepatic cholestasis.
- Similar liver pathology, excluding cholestasis, was observed in mice xenografted with the tumor cell lines.
Conclusions:
- CSF-producing tumors are associated with distinct liver damage.
- This study suggests a new paraneoplastic syndrome characterized by leukocytosis and liver damage.