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Adhesion molecule expression in human synovial tissue

B A Johnson1, G K Haines, L A Harlow

  • 1Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611.

Arthritis and Rheumatism
|February 1, 1993
PubMed
Summary
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Cellular adhesion molecules CD31, CD44, and beta 3-integrin are upregulated in rheumatoid arthritis (RA) synovial tissues, potentially increasing leukocyte recruitment to inflamed joints. Other selectins and integrins show no significant upregulation in RA synovium.

Area of Science:

  • Immunology
  • Rheumatology
  • Cell Biology

Background:

  • Rheumatoid arthritis (RA) involves chronic inflammation of synovial tissues.
  • Leukocyte recruitment to inflamed joints is a key process in RA pathogenesis.
  • E-selectin expression in RA synovium suggests a role for adhesion molecules in leukocyte infiltration.

Purpose of the Study:

  • To investigate the expression of various cellular adhesion molecules in rheumatoid arthritis (RA) synovial tissues.
  • To compare the expression of selectins, integrins, and immunoglobulin supergene family members in RA, osteoarthritis (OA), and normal synovial tissues.
  • To determine the specific adhesion molecules that are differentially expressed in RA synovium.

Main Methods:

  • Immunohistochemical staining was used to analyze synovial tissue samples.

Related Experiment Videos

  • Expression levels of CD31 (PECAM), CD44, CD62 (P-selectin), Leu-8 (L-selectin), and integrin subunits alpha 5, alpha 6, beta 1, and beta 3 were assessed.
  • Samples were obtained from patients with RA, OA, and healthy normal (NL) subjects.

    • Main Results:

    • P-selectin and L-selectin were not differentially expressed in RA synovial tissues.
    • CD31 and CD44 expression was significantly higher on RA lining cells and macrophages compared to OA.
    • Beta 3-integrin was strongly expressed on RA synovial blood vessels, unlike in NL subjects.

    Conclusions:

    • The expression of P-selectin, L-selectin, and certain integrins (VLA 1-6) is not upregulated in RA synovium.
    • CD31, CD44, and beta 3-integrin show increased expression in RA synovial tissues.
    • Upregulation of CD31, CD44, and beta 3-integrin may contribute to leukocyte passage and retention in inflamed RA joints.