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Red blood cell "ghosts" as look-alikes for infectious organisms. A report of two cases
D A Wasdahl1, J R Goellner, B W Scheithauer
1Department of Laboratory Medicine, Mayo Clinic, Rochester, Minnesota 55905.
Acta Cytologica
|January 1, 1993
Abstract:
Two cases are reported in which degenerated red blood cells were initially interpreted as representing infectious organisms. The morphology and staining characteristics of the altered red blood cells are discussed.
Insights
Degenerated red blood cells can mimic infectious organisms on microscopic examination. Understanding their distinct morphology and staining is crucial for accurate diagnosis in clinical pathology.
Area of Science:
- Hematology
- Clinical Pathology
- Medical Laboratory Science
Background:
- Accurate identification of microorganisms is critical for patient treatment.
- Red blood cell morphology can be altered by various degenerative processes.
- Misinterpretation of cellular morphology can lead to diagnostic errors.
Observation:
- Two cases presented with degenerated red blood cells.
- These altered red blood cells were initially mistaken for infectious agents.
- Specific morphological and staining features were noted in the degenerated erythrocytes.
Findings:
- Degenerated red blood cells exhibit characteristic changes in shape and staining.
- These changes can be confused with certain pathogenic microorganisms.
- Detailed analysis of erythrocyte morphology aids in differentiation.
Implications:
- Highlights the importance of careful microscopic evaluation in diagnostic laboratories.
- Emphasizes the need for continuous training in recognizing subtle cellular changes.
- Prevents misdiagnosis and inappropriate antimicrobial therapy.