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Chorionic villus sampling followed by amniocentesis in the same pregnancy
A E Donnenfeld1, R J Librizzi, L K Dunn
1Department of Obstetrics and Gynecology, Pennsylvania Hospital, Philadelphia 19107.
American Journal of Medical Genetics
|February 1, 1993
Summary
A small percentage of chorionic villus sampling (CVS) patients require a follow-up amniocentesis due to various reasons. Genetic counseling should be tailored to institutional data for prenatal diagnosis accuracy.
Area of Science:
- Perinatology
- Prenatal Diagnosis
- Medical Genetics
Background:
- Chorionic villus sampling (CVS) is a common prenatal diagnostic procedure.
- Subsequent amniocentesis may be necessary in some pregnancies following CVS.
- Understanding the indications for repeat procedures is crucial for patient counseling.
Purpose of the Study:
- To determine the incidence and indications for subsequent amniocentesis after CVS.
- To inform patients about potential follow-up procedures.
- To highlight the importance of institution-specific data for genetic counseling.
Main Methods:
- Retrospective analysis of 2,574 consecutive chorionic villus sampling (CVS) cases.
- Identification of patients who underwent a second procedure (amniocentesis) in the same pregnancy.
- Categorization of indications for the subsequent amniocentesis.
Main Results:
- A total of 146 women (5.7%) required a subsequent amniocentesis.
- Indications included absent/insufficient villi (3.3%), elevated maternal serum alpha-fetoprotein (0.93%), CVS mosaicism (0.89%), culture failure (0.23%), specimen contamination (0.15%), and CVS aneuploidy (0.12%).
Conclusions:
- A small but significant proportion of CVS procedures necessitate a follow-up amniocentesis.
- Informed consent for CVS should include the possibility of a subsequent amniocentesis.
- Prenatal diagnosis programs should utilize institutional data to refine genetic counseling.