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Fetal hemoglobin quantitations using the Hemocue system are rapid and accurate
S M Berry1, M P Dombrowski, W B Blessed
1Department of Obstetrics and Gynecology, Wayne State University/Hutzel Hospital, Detroit, Michigan.
Obstetrics and Gynecology
|March 1, 1993
Summary
The Hemocue system accurately quantifies fetal hemoglobin from blood samples. Its precision is unaffected by gestational age or extreme hemoglobin levels in fetuses between 18-38 weeks gestation.
Area of Science:
- Perinatal medicine
- Clinical chemistry
Background:
- Accurate fetal hemoglobin quantitation is crucial for managing conditions like hemolytic disease of the newborn.
- Traditional laboratory methods can be time-consuming and require larger sample volumes.
Purpose of the Study:
- To evaluate the accuracy of the Hemocue system for fetal hemoglobin measurement.
- To assess the influence of gestational age and hemoglobin extremes on Hemocue accuracy.
Main Methods:
- Fetal blood samples (n=58) from 18-38 weeks gestation were analyzed using both Hemocue and Coulter S-Plus IV systems.
- Linear regression analyzed correlation between the two methods.
- Stepwise regression assessed the impact of gestational age and hemoglobin level extremes.
Main Results:
- Hemocue and Coulter systems showed strong correlation (r=0.94, P < .0001).
- Mean values were comparable: Hemocue 12.0 ± 2.4 g/dL, Coulter 11.7 ± 2.3 g/dL.
- Gestational age and hemoglobin extremes did not significantly impact Hemocue accuracy.
Conclusions:
- The Hemocue system provides rapid and accurate fetal hemoglobin quantitation.
- It is reliable for use between 18-38 weeks gestation, irrespective of gestational age or hemoglobin level variations.