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Delayed umbilical cord separation in alloimmune neutropenia
1Department of Immunology, Royal Children's Hospital, Parkville, Melbourne, Australia.
Archives of Disease in Childhood
|January 1, 1993
Summary
Neonatal alloimmune neutropenia can cause delayed umbilical cord separation. This condition involves a deficiency in neutrophil numbers, a factor to consider in such cases.
Area of Science:
- Neonatal immunology
- Hematology
Background:
- Delayed umbilical cord separation (DUCS) is a recognized clinical sign.
- DUCS has been previously associated with neutrophil function defects.
Observation:
- A case of delayed umbilical cord separation in a neonate is presented.
- The neonate was diagnosed with neonatal alloimmune neutropenia (NA N).
Findings:
- Neonatal alloimmune neutropenia is characterized by a deficiency in neutrophil number.
- This case suggests that neutropenia, not just impaired neutrophil function, can cause DUCS.
Implications:
- Neutrophil deficiency should be considered in the differential diagnosis of DUCS.
- Early identification of NA N can guide appropriate management for neonates with DUCS.