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Imaging G-protein Coupled Receptor (GPCR)-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum
Published on: September 20, 2011
Membrane-delimited cell signaling complexes: direct ion channel regulation by G proteins
1Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030.
Abstract:
Ion channels are signaling molecules and by themselves perform no work. In this regard they are unlike the usual membrane enzyme effectors for G proteins. The pathways of G protein receptor, G protein and ion channels are, therefore, purely informational in function. Because a single G protein may have several ion channels as effectors, the effects should be coordinated and this seems to be the case. Inhibition of Ca2+ current and stimulation of K+ currents would have a greater impact than either alone. Additional flexibility is provided by spontaneous noise in the complexes of G protein receptor, G protein, and ion channel. By having a non-zero setpoint, the range of control is extended and the responses become bi-directional.
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