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Osteosarcoma with epithelioid features. An immunohistochemical study

T Hasegawa1, T Shibata, T Hirose

  • 1First Department of Pathology, University of Tokushima School of Medicine, Japan.

Archives of Pathology & Laboratory Medicine
|March 1, 1993
PubMed
Summary

This study details an unusual osteosarcoma case in a 49-year-old man, featuring both bone and carcinoma-like cells. Immunohistochemistry revealed coexpression of epithelial and mesenchymal markers, offering new insights into this rare bone cancer.

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Area of Science:

  • Oncology
  • Pathology
  • Immunohistochemistry

Background:

  • Osteosarcoma is a primary bone malignancy typically exhibiting mesenchymal differentiation.
  • Epithelioid features in osteosarcoma are rare and their immunohistochemical profile is not well-characterized.

Observation:

  • A case of osteosarcoma in the second lumbar vertebra of a 49-year-old male is presented.
  • Histological examination revealed typical osteosarcoma patterns alongside areas resembling carcinoma with epithelioid cells.
  • Immunohistochemistry showed coexpression of mesenchymal markers (osteocalcin) and epithelial markers (cytokeratin, epithelial membrane antigen) in tumor cells.

Findings:

  • The osteosarcoma demonstrated both typical osteosarcoma histology and distinct epithelioid cell areas.
  • Tumor cells exhibited immunoreactivity for osteocalcin, cytokeratin, and epithelial membrane antigen.

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  • No evidence of metastatic disease or other primary malignancy was found.

    • Implications:

    • This case highlights the diagnostic challenge posed by osteosarcomas with divergent differentiation.
    • The immunohistochemical findings expand the understanding of osteosarcoma heterogeneity.
    • Further research into epithelioid osteosarcomas is warranted to clarify their behavior and treatment strategies.