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B and T lymphocyte subsets in fetal and cord blood: age-related modulation of CD1c expression
A Plebani1, A R Proserpio, D Guarneri
11st Clinica Pediatrica G. e. D. DeMarchi, Università di Milano, Italy.
Biology of the Neonate
|January 1, 1993
Abstract:
Peripheral blood lymphocytes from fetal, term and adult subjects were analyzed with a panel of B- and T-lymphoid differentiation markers. CD1c +ve and CD5 +ve B cell (IgM +ve) percentage in fetal, cord and adult blood decreased significantly. Fetal and cord blood contained less CD2+ and CD3+ T lymphocytes and a higher percentage of CD38 +ve cells than adult blood. The phenotypic changes occurring during perinatal age in humans relate to the changes in the functional activities of the B and T lymphoid subsets from fetal to postnatal age.