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[Anti/TSH antibodies in thyroidal diseases]
Nihon Naibunpi Gakkai Zasshi
|January 20, 1993
Summary
TSH binding antibodies, discovered via negative TSH receptor antibody (TRAb) assays, primarily target the alpha-subunit of bovine pituitary glycoprotein hormones. These antibodies show cross-reactivity across mammalian species, excluding humans.
Area of Science:
- Endocrinology
- Immunology
- Molecular Biology
Context:
- Negative TSH receptor antibody (TRAb) assay results revealed the presence of TSH binding antibodies.
- Anti-TSH antibodies are associated with thyroid diseases like Graves' disease and Hashimoto's thyroiditis.
- The idiotype-anti-idiotype relationship between TRAb and anti-TSH antibodies remains unclear.
Purpose:
- To investigate the characteristics and target epitopes of TSH binding antibodies.
- To determine the cross-reactivity of TSH binding antibodies with various hormones and species.
Summary:
- TSH binding antibodies were identified and found not to be inhibited by TRAb.
- These antibodies reacted with bovine and porcine TSH, FSH, and LH, specifically targeting the alpha-subunit.
- Reactivity was observed across multiple mammalian species but not in humans.
Impact:
- Identifies the alpha-subunit of bovine pituitary glycoprotein hormones as a key epitope for TSH binding antibodies.
- Provides insights into the immunobiology of thyroid diseases and potential diagnostic markers.
- Suggests a basis for understanding cross-species reactivity in hormone-binding antibodies.