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The cell cycle and c-Src

S J Taylor1, D Shalloway

  • 1Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853.

Current Opinion in Genetics & Development
|February 1, 1993
PubMed
Summary
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The activity of the proto-oncogene c-Src is tightly controlled in the body. Researchers have identified protein kinases and phosphatases that regulate c-Src, particularly during the cell cycle.

Area of Science:

  • Molecular Biology
  • Cellular Regulation
  • Oncogene Signaling

Background:

  • The proto-oncogene c-Src plays a critical role in cellular processes.
  • Its activity must be precisely regulated within the cell.
  • Dysregulation of c-Src is implicated in various diseases, including cancer.

Purpose of the Study:

  • To elucidate the regulatory mechanisms governing c-Src activity in vivo.
  • To identify key protein kinases and phosphatases involved in c-Src regulation.
  • To understand the role of these regulators in the context of the cell cycle.

Main Methods:

  • Characterization of protein kinases.
  • Identification of protein phosphatases.
  • In vivo studies of c-Src regulation during the cell cycle.

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Main Results:

  • Several protein kinases and phosphatases have been identified as regulators of c-Src.
  • These enzymes play a significant role in controlling c-Src activity.
  • The identified regulators are active during specific phases of the cell cycle.

Conclusions:

  • A model for the regulation of c-Src activity has been proposed.
  • Protein kinases and phosphatases are crucial for maintaining c-Src homeostasis.
  • Understanding these regulatory pathways is vital for therapeutic interventions targeting c-Src-related pathologies.