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Source analysis of scalp-recorded movement-related electrical potentials
C Toro1, J Matsumoto, G Deuschl
1Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
Electroencephalography and Clinical Neurophysiology
|March 1, 1993
Summary
Brain electric source analysis reveals bilateral sensorimotor cortex generators for the negative slope peak (pNS') and contralateral/midline sources for the frontal motor potential (fpMP) in finger movements.
Area of Science:
- Neuroscience
- Electrophysiology
- Brain Imaging
Background:
- Movement-related cortical potentials (MRCPs) are crucial for understanding motor control.
- Identifying the precise neural sources of MRCPs remains a challenge.
Purpose of the Study:
- To investigate the neural generators of the peak negative slope (pNS") and frontal peak of the motor potential (fpMP) within MRCPs.
- To analyze activity from 200 msec before to 200 msec after movement onset during self-paced finger movements.
Main Methods:
- Applied brain electric source analysis using dipole solutions on scalp-recorded MRCPs.
- Studied 10 healthy volunteers performing repetitive, unilateral finger movements.
- Utilized a spherical head model to determine source locations for pNS" and fpMP.
Main Results:
- Satisfactory dipole solutions for pNS" activity were found bilaterally in homologous sensorimotor cortex areas for all subjects.
- fpMP activity was modeled by contralateral and midline sources in 6 subjects, and a single contralateral source in 4 subjects.
- Low residual variance indicated a good fit for the derived source models.
Conclusions:
- The findings support the hypothesis that the NS" originates from bilateral generators in the sensorimotor cortex.
- The motor potential (fpMP) appears to arise from the combined activity of contralateral postcentral regions and the supplementary motor area.