Related Experiment Video
Updated: Aug 11, 2026
12:23
Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
Published on: April 14, 2014
The pattern electroretinogram: N95 amplitudes in normal subjects and optic neuritis patients
1Michigan State University, Neuro-Visual Unit, East Lansing 48824.
Electroencephalography and Clinical Neurophysiology
|March 1, 1993
Summary
The N95 peak of the transient pattern electroretinogram (PERG) shows retinal ganglion cell function. A new N95 amplitude measure improved accuracy, correlating with visual recovery in optic neuritis patients.
Area of Science:
- Ophthalmology
- Neuroscience
- Physiology
Background:
- The N95 peak of the transient pattern electroretinogram (PERG) is a potential indicator of late-stage retinal function.
- Previous methods for measuring N95 amplitude showed significant variation.
Purpose of the Study:
- To introduce a novel digital filtering method for measuring N95 amplitude.
- To assess the correlation between N95 amplitude and clinical recovery in optic neuritis patients.
Main Methods:
- A new digital filtering technique was developed to establish a non-linear baseline for N95 amplitude measurement.
- This method was validated in 50 healthy subjects and then applied to 12 patients with optic neuritis.
Main Results:
- The new N95 amplitude measurement significantly reduced variability in normal subjects.
- Normal N95 amplitudes at 6 months post-optic neuritis onset correlated with excellent clinical recovery.
- Reduced N95 amplitudes indicated persistent visual function abnormalities.
Conclusions:
- The N95 peak of the PERG is a reliable indicator of retinal ganglion cell function.
- The novel N95 measurement method enhances diagnostic accuracy for retinal function.
- N95 amplitude is a valuable prognostic marker for recovery after optic neuritis.
