Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Amiodarone interaction with lidocaine

J B Siegmund1, J H Wilson, T E Imhoff

  • 1Good Samaritan Hospital, Cincinnati, OH 45220.

Journal of Cardiovascular Pharmacology
|April 1, 1993
PubMed
Summary

A case study reveals a dangerous drug interaction between amiodarone and lidocaine. Amiodarone can increase lidocaine levels, leading to toxicity and seizures, highlighting the need for careful monitoring.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Frustration-Free Control and Absorbing-State Transport in Entangled State Preparation.

Physical review letters·2026
Same author

Operator Scaling Dimensions and Multifractality at Measurement-Induced Transitions.

Physical review letters·2022
Same author

Using syndromic surveillance to estimate baseline rates for healthcare-associated infections in critical care units of small animal referral hospitals.

Journal of veterinary internal medicine·2013
Same author

Balanced anaesthesia in oral and facio-maxillary surgery.

The Dental journal of Australia·2010
Same author

Viburnum Prunifolium, or Black Haw, in Abortion and Miscarriage.

British medical journal·2010
Same author

The man agement and nursing care of craniocerebral injuries.

The Trained nurse and hospital review·2010

Area of Science:

  • Pharmacology
  • Clinical Toxicology
  • Drug Interactions

Background:

  • Lidocaine is a commonly used antiarrhythmic and local anesthetic.
  • Amiodarone is a potent antiarrhythmic drug with a complex pharmacokinetic profile.
  • Potential drug interactions between amiodarone and other medications are a significant clinical concern.

Observation:

  • A patient developed lidocaine toxicity, including seizures, after initiating amiodarone therapy.
  • Toxic lidocaine levels and decreased lidocaine clearance were observed 65 hours post-amiodarone initiation.
  • This represents the first documented instance of amiodarone causing increased lidocaine levels and toxicity.

Findings:

  • Amiodarone significantly alters the metabolism of lidocaine.
  • The interaction appears to be mediated by amiodarone-induced changes in hepatic enzyme activity.
  • Reduced clearance of lidocaine contributes to its accumulation and toxicity.

Implications:

  • Clinicians should exercise caution when co-prescribing amiodarone and lidocaine.
  • Close monitoring of lidocaine levels and clinical signs of toxicity is crucial in patients receiving both drugs.
  • This interaction underscores the importance of understanding drug metabolism pathways and potential interactions in clinical practice.

Related Experiment Videos