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[The modifications of mutagenesis and anticarcinogenesis]

V V Khudoleĭ

    Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
    |January 1, 1993
    PubMed

    Insights

    This study explores anticarcinogenesis by examining multistage carcinogenesis mechanisms. It highlights promising agents like nitrosation modifiers and dietary sorbents for cancer prevention, emphasizing effective screening methods.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Toxicology

    Context:

    • Discusses anticarcinogenesis within the framework of mechanistic approaches.
    • Highlights the complex, multistage nature of carcinogenesis involving extra- and intracellular events.
    • Addresses the challenges in identifying effective cancer prevention strategies.

    Purpose:

    • To review and discuss mechanistic approaches to anticarcinogenesis.
    • To identify promising agents and strategies for suppressing chemical carcinogenesis.
    • To evaluate the suitability of mutagenicity and anticarcinogenesis bioassays for agent screening.

    Summary:

    • Reviews multistage carcinogenesis mechanisms and related molecular events.
    • Identifies key classes of anticarcinogenic agents, including nitrosation modifiers, dietary sorbents, metabolic modulators, and gene expression inhibitors.
    • Recommends short-term mutagenicity tests for screening anticarcinogenic agents and emphasizes the need for sensitive, specific, and predictive anticarcinogenesis bioassays.

    Impact:

    • Provides a comprehensive overview of anticarcinogenesis strategies.
    • Guides the selection and development of novel cancer prevention agents.
    • Informs the design of more effective screening protocols for potential anticancer drugs.

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