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Related Experiment Videos

Major amputation for malignant melanoma: an epidemiological study

L B Ebskov1

  • 1Danish Amputation Register, Department of Orthopaedic Surgery, Herlev Hospital, Vaerloese.

Journal of Surgical Oncology
|February 1, 1993
PubMed
Summary

Malignant melanoma amputations in Denmark remained constant, but limb melanomas increased. Survival rates after amputation are low, particularly for females, with mortality linked to sex and amputation level.

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Epidemiology

Background:

  • Malignant melanoma is a significant cause of limb amputation.
  • Trends in amputation rates and patient demographics require ongoing study.

Purpose of the Study:

  • To analyze amputation rates for malignant melanoma in Denmark from 1978-1987.
  • To compare demographic factors and survival outcomes with existing literature.
  • To review indications for amputation in malignant melanoma cases.

Main Methods:

  • Retrospective analysis of amputation data for malignant melanoma.
  • Kaplan-Meier survival analysis.
  • Literature review for comparative demographic analysis.

Main Results:

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  • Constant annual amputation rates for malignant melanoma limbs, but increasing numbers of extremity melanomas.
  • Higher mean age at amputation in Denmark (approx. 65 years) compared to previous studies (approx. 45 years).
  • Lower limb amputation: mean age 58 (males) and 72 (females); sex ratio M:F 1:2.2.
  • 5-year survival rate approximately 28%; mortality associated with sex and amputation level.
  • Higher mortality observed in females (74% after 19 months) compared to males (54% after 18 months).

Conclusions:

  • Amputation for malignant melanoma in Denmark shows specific demographic trends and poor survival outcomes.
  • Mortality is significantly influenced by patient sex and the level of amputation.
  • Amputation is rarely indicated, primarily for palliative care in malignant melanoma cases.