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Malignant germ cell tumours in two siblings
1Department of Paediatric Oncology, Children's Hospital, Sheffield, England.
Medical and Pediatric Oncology
|January 1, 1993
Abstract:
Familial germ cell tumours are well recognised in kinship with gonadal dysgenesis, but their occurrence in siblings with normal chromosomes is rare. We report two sisters who presented within a 4 month period with malignant ovarian germ cell tumours; one a dysgerminoma and the other a mixed tumour with marked choriocarcinomatous elements. Both children had a normal female constitutional karyotype and normal phenotype.