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Published on: August 16, 2011
Schistosoma mansoni: analysis of monoclonal antibodies reactive with gut-associated antigens
G J van Dam1, D Kornelis, R J Van Zeyl
1Laboratory for Parasitology, University of Leiden, The Netherlands.
The analysis of a series of monoclonal antibodies (mAbs) developed in our laboratory against gut-associated antigens of Schistosoma mansoni is described. It was found that mAbs that recognized epitopes of antigens in the gut and on the eggshell were mainly of the IgM isotype; these epitopes are likely to be carbohydrate in composition. Of a number of mAbs that were reactive with antigens important to the human humoral immune response, 75% appeared to be reactive with the circulating cathodic antigen.
The analysis of a series of monoclonal antibodies (mAbs) developed in our laboratory against gut-associated antigens of Schistosoma mansoni is described. It was found that mAbs that recognized epitopes of antigens in the gut and on the eggshell were mainly of the IgM isotype; these epitopes are likely to be carbohydrate in composition. Of a number of mAbs that were reactive with antigens important to the human humoral immune response, 75% appeared to be reactive with the circulating cathodic antigen.
