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Keratoacanthoma with glandular proliferation

M Akiyama¹, Y Hata, T Nishikawa

¹Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.

The Journal of Dermatology

|February 1, 1993

Summary

This study reports the first case of keratoacanthoma (KA) with true glandular proliferation, observed in an 82-year-old male. The glandular structures showed apocrine gland characteristics, suggesting a potential origin.

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Area of Science:

Dermatopathology
Oncology

Background:

Keratoacanthoma (KA) is a common skin tumor, typically of follicular origin.
While adenoid structures can occur due to acantholysis, true glandular proliferation within KA is rare.

Observation:

A unique case of keratoacanthoma (KA) was identified in an 82-year-old Japanese male presenting as a cheek nodule.
Histopathological examination revealed typical KA features alongside a distinct glandular structure at the lesion base.
Immunohistochemistry showed carcinoembryonic antigen positivity in the glandular structure, with lectin binding patterns resembling apocrine glands.

Findings:

The glandular proliferation exhibited features suggestive of apocrine origin, distinct from typical KA.
This represents the first documented instance of keratoacanthoma associated with genuine glandular proliferation.

Implications:

This case expands the understanding of keratoacanthoma's histopathological spectrum.
The findings suggest a potential link between KA and apocrine differentiation, warranting further investigation into tumor origins.

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