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Chromatid-type aberrations induced by AluI in Chinese hamster ovary cells
G Obe1, C Johannes, I Werthmann
1Department of Genetics, Universität GH Essen, Germany.
Mutation Research
|May 1, 1993
Abstract:
Treatment of CHO cells with AluI in the S-phase leads to chromatid-type aberrations whose frequencies are linearly correlated with dose. Treatment in the S-phase leads to fewer aberrations than treatment in the G1-phase, which is comparable to chromosomal aberration induction following X-irradiation in the G1- and S-phases. Treatment in the G1-phase leads to few chromatid-type interchanges, some of these may originate from DNA single-strand gaps induced by AluI in canonical structures of DNA and in DNA.RNA hybrids.