Related Experiment Video
Updated: Oct 24, 2026

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney
Published on: August 9, 2014
Towards a molecular view of renal proximal tubular reabsorption of phosphate
Abstract:
Apical sodium-dependent transport of inorganic phosphate (Pi) in the proximal tubule plays a crucial role in renal Pi reabsorption and consequently in the maintenance of Pi homeostasis. This transport system represents a main target for acute and long-term regulation such as by parathyroid hormone, by growth factors and dietary intake of phosphate. In this short review we briefly describe the currently established cellular mechanism of proximal tubular Pi reabsorption and its regulation via the apical Na/Pi cotransport system. In a second part we will outline recent progress made with respect to the molecular cloning of renal Na/Pi cotransport systems. Knowledge about the molecular identity of these transport systems will make it possible to resolve yet unanswered questions about the molecular mechanisms involved in the physiology of the regulation of renal Pi reabsorption.
More Related Videos
08:46Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
Published on: September 1, 2015
07:06Isolation of Primary Human Proximal Tubule Epithelial Cells and Their Use in Creating a Microphysiological Model of the Renal Proximal Tubule
Published on: May 9, 2025
Related Concept Videos
Drug Elimination by Renal Route: Tubular Reabsorption
Renal Tubule and Collecting Duct
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Tubular Reabsorption and Secretion
Tubular reabsorption is a selective process that starts when the filtrate enters the proximal tubules. It involves substances traveling through the transcellular route (through the tubule cell and peritubular...
Reabsorption and Secretion in the PCT
Transport mechanisms involving sodium ions (Na+) contribute significantly to solute reabsorption. These mechanisms include symport and antiport processes.
A key example is the...
Renal Drug Excretion: Tubular Secretion
Physiology of the Genitourinary System II: Tubular Reabsorption and Secretion