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Monoclonal antibodies directed against T cell epitopes presented by class I MHC antigens
1INSERM U 267, Immunogénétique des Allogreffes, Hôpital Paul Brousse, Villejuif, France.
International Immunology
|April 1, 1993
Abstract:
Monoclonal antibodies which recognize a synthetic peptide derived from influenza virus nucleoprotein in association with a murine class I MHC molecule (Kd) have been isolated. One such antibody has been characterized and shown to react neither with the peptide nor with the Kd molecule, but only with the Kd-peptide complex. Evidence is given that it recognizes the naturally processed peptide located in the peptide binding groove, i.e. the antigenic moiety presented to T cells.