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Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model
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Published on: July 26, 2011

Postembedding staining of brain tissue for ultrastructural visualization of amyloid in Alzheimer's disease

A Migheli1, A Attanasio, M T Giordana

  • 1Neurological Clinic II, University of Torino, Italy.

Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission
|March 1, 1993
PubMed

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Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...