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Fewer protective cytotoxic T-cell epitopes than T-helper-cell epitopes on vesicular stomatitis virus
T M Kündig1, I Castelmur, M F Bachmann
1Institute of Experimental Immunology, University of Zürich, Switzerland.
Journal of Virology
|June 1, 1993
Abstract:
Cytotoxic T-lymphocyte (CTL) and T-helper-cell responses in various mouse strains were monitored. Protective CTL responsiveness against three proteins of vesicular stomatitis virus was H-2 linked and inducible only in half of the 15 combinations tested (each of five H-2 haplotypes combined with each of three viral proteins), whereas biologically relevant T-helper-cell responses were inducible in all. This suggests that vesicular stomatitis virus exhibits more T-helper-cell than CTL epitopes.