Treatment of drug-induced agranulocytosis with recombinant granulocyte colony-stimulating factor (rh G-CSF)
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A Willfort1, C Lorber, S Kapiotis
1First Department of Internal Medicine, Division of Hematology and Blood Coagulation, Vienna, Austria.
Annals of Hematology
|May 1, 1993
Abstract:
Five patients with drug-induced agranulocytosis received 300 micrograms recombinant human granulocyte colony-stimulating factor (rh G-CSF) subcutaneously twice daily for 2-5 days. G-CSF therapy resulted in a steep increase of the neutrophil count, which was faster than that in patients with spontaneous recovery reported in the literature. In all four patients with infectious complications fever rapidly declined with the increase of granulocytes. G-CSF may be useful in the management of drug-induced agranulocytosis.