Related Experiment Video
Updated: Aug 12, 2026

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
Expression of heat shock protein epitopes in renal disease
S M Dodd1, J E Martin, M Swash
1Department of Morbid Anatomy, Royal London Hospital, Whitechapel, UK.
Abstract:
We have examined the immunohistochemical pattern of staining with antibodies to the 72 kD heat shock protein (HSP72) and ubiquitin in 28 cases of human renal disease. Three distinct patterns of staining were seen with the use of an antibody to HSP72: tubular, intraluminal and interstitial. No glomerular staining was detected. In no cases were ubiquitin epitopes detected. The pattern of staining was most strongly related to the activity of the disease process, positive staining often being present in relation to agents or processes known to upregulate stress protein expression in experimental isolated cellular systems. Stress protein upregulation in human renal disease may represent cellular attempts at cytoprotection in conditions of active sublethal cell toxicity.
Related Concept Videos
Nephrons
Renal Corpuscle
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Nephrotic Syndrome I : Introduction
Nephrotic Syndrome II : Assessment and Medical Management
Acute Kidney Injury II: Pathophysiology
Diabetic Nephropathy

