Related Experiment Videos
Sequential changes in plasma fibronectin in patients with subarachnoid hemorrhage
S Kashiwagi1, Y Shiroyama, T Iwamoto
1Department of Neurosurgery, Yamaguchi University School of Medicine.
Neurologia Medico-Chirurgica
|April 1, 1993
Summary
Plasma fibronectin levels are lower in patients with poor outcomes after subarachnoid hemorrhage (SAH). These decreased fibronectin levels, particularly when associated with vasospasm, can predict clinical outcomes in SAH patients.
Area of Science:
- Neurology
- Biochemistry
Background:
- Subarachnoid hemorrhage (SAH) is a critical neurological condition often caused by ruptured cerebral aneurysms.
- Predicting clinical outcomes in SAH patients remains a significant challenge.
Purpose of the Study:
- To investigate sequential changes in plasma fibronectin levels in SAH patients.
- To correlate fibronectin levels with clinical outcomes and the presence of vasospasm.
Main Methods:
- Plasma fibronectin concentrations were measured using an immune diffusion method.
- Clinical outcomes were assessed using the Glasgow Outcome Scale at 3 months post-SAH.
- Fibronectin levels were compared between patients with good and poor outcomes, and with and without vasospasm.
Main Results:
- Significantly lower plasma fibronectin concentrations were observed on days 3 and 9 post-ictus in patients with poor outcomes.
- Patients experiencing vasospasm exhibited lower fibronectin concentrations throughout the first 4 weeks after ictus.
- Decreased plasma fibronectin levels correlated with poor outcomes, especially when vasospasm was present.
Conclusions:
- Plasma fibronectin levels serve as a valuable indicator of SAH severity.
- Fibronectin levels can be utilized as a predictive marker for the final clinical outcome in SAH patients.